Impact of Paracetamol Impurities on Face Properties: Investigating the Surface of Single Crystals Using TOF-SIMS | Zendy

Sara Ottoboni | Zendy; Michael Chrubasik | Zendy; Layla Mir Bruce | Zendy; Thai Thu Hien Nguyen | Zendy; Murray N. Robertson | Zendy; Blair F. Johnston | Zendy; Iain D. H. Oswald | Zendy; Alastair J. Florence | Zendy; C. Price | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Impact of Paracetamol Impurities on Face Properties: Investigating the Surface of Single Crystals Using TOF-SIMS

Author(s) -

Sara Ottoboni,

Michael Chrubasik,

Layla Mir Bruce,

Thai Thu Hien Nguyen,

Murray N. Robertson,

Blair F. Johnston,

Iain D. H. Oswald,

Alastair J. Florence,

C. Price

Publication year - 2018

Publication title -

crystal growth and design

Language(s) - English

Resource type - Journals

eISSN - 1528-7505

pISSN - 1528-7483

DOI - 10.1021/acs.cgd.7b01411

Subject(s) - impurity , crystallization , raman spectroscopy , secondary ion mass spectrometry , x ray photoelectron spectroscopy , analytical chemistry (journal) , chemistry , crystal (programming language) , scanning electron microscope , characterization (materials science) , mass spectrometry , materials science , crystallography , nanotechnology , chemical engineering , chromatography , optics , organic chemistry , physics , computer science , composite material , programming language , engineering

Understanding the mechanism of interaction between pharmaceutical molecules (APIs) and impurities on crystal surfaces is a key concept in understanding purification and for the design of pharmaceutical crystallization processes. Several techniques may be used to study crystal surface properties, such as scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS), which provide detailed imaging and elemental surface characterization. Time of flight secondary ion mass spectrometry (TOF-SIMS) is valuable in determining molecular identity and distribution. By combining TOF-SIMS, SEM, and optical (OM) and Raman microscopies, we can evaluate the usefulness of TOF-SIMS as a surface characterization technique for pharmaceutical crystals. 4-Nitrophenol has been selected as an impurity that can be incorporated during crystallization of acetaminophen (paracetamol). This study explores the distribution of impurity and its concentration on the different crystal faces of samples obtained by crystalliz...

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research