Continuous Cocrystallization of Benzoic Acid and Isonicotinamide by Mixing-Induced Supersaturation: Exploring Opportunities between Reactive and Antisolvent Crystallization Concepts | Zendy

Václav Svoboda | Zendy; Pól MacFhionnghaile | Zendy; John McGinty | Zendy; Lauren E. Connor | Zendy; Iain D. H. Oswald | Zendy; Ján Šefčı́k | Zendy

Open Access

Continuous Cocrystallization of Benzoic Acid and Isonicotinamide by Mixing-Induced Supersaturation: Exploring Opportunities between Reactive and Antisolvent Crystallization Concepts

Author(s) -

Václav Svoboda,

Pól MacFhionnghaile,

John McGinty,

Lauren E. Connor,

Iain D. H. Oswald,

Ján Šefčı́k

Publication year - 2017

Publication title -

crystal growth and design

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.966

H-Index - 155

eISSN - 1528-7505

pISSN - 1528-7483

DOI - 10.1021/acs.cgd.6b01866

Subject(s) - cocrystal , isonicotinamide , crystallization , supersaturation , mixing (physics) , benzoic acid , solvent , materials science , chemical engineering , chemistry , crystallography , molecule , organic chemistry , hydrogen bond , physics , quantum mechanics , engineering

This study combines reactive and antisolvent crystallization concepts via mixing-induced supersaturation to demonstrate a wider range of options for solvent system selection in multicomponent crystallization. This approach was applied to investigate continuous crystallization of 1:1 and 2:1 cocrystals of benzoic acid and isonicotinamide. Design of Experiments was used to identify conditions where pure cocrystal phases are obtained and a continuous mixing-induced cocrystallization process was implemented to selectively produce either 1:1 or 2:1 cocrystals

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