Impact of Mixed Solvent on Co-Crystal Solubility, Ternary Phase Diagram, and Crystallization Scale Up | Zendy

Tasnim Munshi | Zendy; Batul H. Redha | Zendy; N. Feeder | Zendy; Paul Meenan | Zendy; N. Blagden | Zendy

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Impact of Mixed Solvent on Co-Crystal Solubility, Ternary Phase Diagram, and Crystallization Scale Up

Author(s) -

Tasnim Munshi,

Batul H. Redha,

N. Feeder,

Paul Meenan,

N. Blagden

Publication year - 2016

Publication title -

crystal growth and design

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.966

H-Index - 155

eISSN - 1528-7505

pISSN - 1528-7483

DOI - 10.1021/acs.cgd.5b00908

Subject(s) - crystallization , solubility , isonicotinamide , solvent , phase diagram , crystal (programming language) , phase (matter) , chemistry , ternary operation , dissolution , thermodynamics , materials science , crystallography , chemical engineering , organic chemistry , molecule , computer science , physics , hydrogen bond , programming language , engineering

This contribution covers the identification, understanding, and rationale of the interplay between the choice of mixed solvent on the crystallization of the co-crystal system benzoic acid and isonicotinamide (BZ:INA). A critical first step was gauging the impact of solvent choice and composition on the overall crystallization process, across a number of temperature points. This required defining the solubility and phase diagrams of the co-crystal system at specified temperatures, which reflects the cooling by crystallization profile encountered in a batch crystallization step. To this end,\udidentifying and understanding the impact of solvent composition over a selected temperature range on the solubility of co-crystal underpins this contribution

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