In Situ Synthesis of Magnetic Field-Responsive Hemicellulose Hydrogels for Drug Delivery | Zendy

Weifeng Zhao | Zendy; Karin Odelius | Zendy; Ulrica Edlund | Zendy; Changsheng Zhao | Zendy; AnnChristine Albertsson | Zendy

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In Situ Synthesis of Magnetic Field-Responsive Hemicellulose Hydrogels for Drug Delivery

Author(s) -

Weifeng Zhao,

Karin Odelius,

Ulrica Edlund,

Changsheng Zhao,

AnnChristine Albertsson

Publication year - 2015

Publication title -

biomacromolecules

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.689

H-Index - 220

eISSN - 1526-4602

pISSN - 1525-7797

DOI - 10.1021/acs.biomac.5b00801

Subject(s) - self healing hydrogels , hemicellulose , drug delivery , chemical engineering , materials science , magnetic nanoparticles , bovine serum albumin , swelling , adsorption , nanoparticle , nanotechnology , chemistry , controlled release , organic chemistry , polymer chemistry , chromatography , composite material , cellulose , engineering

A one-pot synthetic methodology for fabricating stimuli-responsive hemicellulose-based hydrogels was developed that consists of the in situ formation of magnetic iron oxide (Fe3O4) nanoparticles during the covalent cross-linking of O-acetyl-galactoglucomannan (AcGGM). The Fe3O4 nanoparticle content controlled the thermal stability, macrostructure, swelling behavior, and magnetization of the hybrid hydrogels. In addition, the magnetic field-responsive hemicellulose hydrogels (MFRHHs) exhibited excellent adsorption and controlled release profiles with bovine serum albumin (BSA) as the model drug. Therefore, the MFRHHs have great potential to be utilized in the biomedical field for tissue engineering applications, controlled drug delivery, and magnetically assisted bioseparation. Magnetic field-responsive hemicellulose hydrogels, prepared using a straightforward one-step process, expand the applications of biomass-derived polysaccharides by combining the renewability of hemicellulose and the magnetism of Fe3O4 nanoparticles.

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