Magnetite Nanoparticles for Stem Cell Labeling with High Efficiency and Long-Term in Vivo Tracking | Zendy

Noelia Guldris | Zendy; Bárbara Argibay | Zendy; Juan Gallo | Zendy; Ramón IglesiasRey | Zendy; Enrique CarbóArgibay | Zendy; Yury V. Kolen’ko | Zendy; Francisco Campos | Zendy; Tomás Sobrino | Zendy; Laura M. Salonen | Zendy; Manuel BañobreLópez | Zendy; José Castillo | Zendy; J. Rivas | Zendy

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Magnetite Nanoparticles for Stem Cell Labeling with High Efficiency and Long-Term in Vivo Tracking

Author(s) -

Noelia Guldris,

Bárbara Argibay,

Juan Gallo,

Ramón IglesiasRey,

Enrique CarbóArgibay,

Yury V. Kolen’ko,

Francisco Campos,

Tomás Sobrino,

Laura M. Salonen,

Manuel BañobreLópez,

José Castillo,

J. Rivas

Publication year - 2016

Publication title -

bioconjugate chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.279

H-Index - 172

eISSN - 1520-4812

pISSN - 1043-1802

DOI - 10.1021/acs.bioconjchem.6b00522

Subject(s) - chemistry , in vivo , iron oxide nanoparticles , internalization , nanoparticle , iron oxide , biocompatibility , polylysine , mesenchymal stem cell , magnetite nanoparticles , biophysics , surface modification , stem cell , glucosamine , cell , magnetic resonance imaging , magnetic nanoparticles , nanotechnology , biochemistry , microbiology and biotechnology , materials science , medicine , organic chemistry , radiology , biology

Superparamagnetic iron oxide nanoparticles (SPIO-PAA), ultrasmall iron oxide nanoparticles (USPIO-PAA), and glucosamine-modified iron oxide nanoparticles (USPIO-PAA-GlcN) were studied as mesenchymal stem cell (MSCs) labels for cell tracking applications by magnetic resonance imaging (MRI). Pronounced differences were found in the labeling performance of the three samples in terms of cellular dose and labeling efficiency. In combination with polylysine, SPIO-PAA showed nonhomogeneous cell internalization, while for USPIO-PAA no uptake was found. On the contrary, USPIO-PAA-GlcN featured high cellular uptake and biocompatibility, and sensitive detection in both in vitro and in vivo experiments was found by MRI, showing that glucosamine functionalization can be an efficient strategy to increase cell uptake of ultrasmall iron oxide nanoparticles by MSCs.

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