Open AccessSolid Lipid Nanoparticles for Image-Guided Therapy of Atherosclerosis
Author(s) -
Khalid Oumzil,
M. Ramin,
Cyril Lorenzato,
Audrey Hémadou,
Jeanny Laroche,
Marie Josée Jacobin-Valat,
Stéphane Mornet,
Claude-Eric Roy,
Tina Kauss,
Karen Gaudin,
Gisèle ClofentSanchez,
Philippe Barthélémy
Publication year - 2016
Publication title -
bioconjugate chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.279
H-Index - 172
eISSN - 1520-4812
pISSN - 1043-1802
DOI - 10.1021/acs.bioconjchem.5b00590
Subject(s) - context (archaeology) , chemistry , solid lipid nanoparticle , nanoparticle , platelet aggregation , nucleoside , magnetic resonance imaging , nanotechnology , platelet , biochemistry , radiology , medicine , materials science , paleontology , biology
Although the application of nanotechnologies to atherosclerosis remains a young field, novel strategies are needed to address this public health issue. In this context, the magnetic resonance imaging (MRI) approach has been gradually investigated in order to enable image-guided treatments. In this contribution, we report a new approach based on nucleoside-lipids allowing the synthesis of solid lipid nanoparticles (SLN) loaded with iron oxide particles and therapeutic agents. The insertion of nucleoside-lipids allows the formation of stable SLNs loaded with prostacycline (PGI2) able to inhibit platelet aggregation. The new SLNs feature better relaxivity properties in comparison to the clinically used contrast agent Feridex, indicating that SLNs are suitable for image-guided therapy.
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