Methods for the Analysis of Polyphosphate in the Life Sciences | Zendy

Jonas Johannes Christ | Zendy; Sabine Willbold | Zendy; Lars M. Blank | Zendy

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Methods for the Analysis of Polyphosphate in the Life Sciences

Author(s) -

Jonas Johannes Christ,

Sabine Willbold,

Lars M. Blank

Publication year - 2020

Publication title -

analytical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.117

H-Index - 332

eISSN - 1520-6882

pISSN - 0003-2700

DOI - 10.1021/acs.analchem.9b05144

Subject(s) - polyphosphate , chemistry , long chain , characterization (materials science) , polymer , biophysics , function (biology) , nanotechnology , polymer science , computational biology , biological system , biochemistry , organic chemistry , microbiology and biotechnology , phosphate , materials science , biology

Inorganic polyphosphate (polyP) is the polymer of orthophosphate and can be found in all living organisms. For polyP characterization, one or more of six parameters are of interest: the molecular structure (linear, cyclic, or branched), the concentration, the average chain length, the chain length distribution, the cellular localization, and the cation composition. Here, the merits, limitations, and critical parameters of the state-of-the-art methods for the analysis of the six parameters from the life sciences are discussed. With this contribution, we aim to lower the entry barrier into the analytics of polyP, a molecule with prominent, yet often incompletely understood, contributions to cellular function.

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