Monitorable Mitochondria-Targeting DNAtrain for Image-Guided Synergistic Cancer Therapy | Zendy

Tao Jiang | Zendy; Lihua Zhou | Zendy; Haixiang Liu | Zendy; Pengfei Zhang | Zendy; Guozhen Liu | Zendy; Ping Gong | Zendy; Chunbin Li | Zendy; Weihong Tan | Zendy; Jianhai Chen | Zendy; Lintao Cai | Zendy

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Monitorable Mitochondria-Targeting DNAtrain for Image-Guided Synergistic Cancer Therapy

Author(s) -

Tao Jiang,

Lihua Zhou,

Haixiang Liu,

Pengfei Zhang,

Guozhen Liu,

Ping Gong,

Chunbin Li,

Weihong Tan,

Jianhai Chen,

Lintao Cai

Publication year - 2019

Publication title -

analytical chemistry

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.117

H-Index - 332

eISSN - 1520-6882

pISSN - 0003-2700

DOI - 10.1021/acs.analchem.9b01777

Subject(s) - chemistry , mitochondrion , reactive oxygen species , drug delivery , cancer , cancer therapy , cancer research , adjuvant , cancer cell , targeted drug delivery , chemotherapy , pharmacology , biochemistry , oncology , medicine , organic chemistry

It is highly desirable to realize real-time monitoring of the drug delivery/release process in cancer treatment. Herein, a monitorable mitochondria-specific DNAtrain (MitoDNAtrs) was developed for image-guided drug delivery and synergistic cancer therapy. In this system, mitochondria-targeting Cy5.5 dye served as the "locomotive" to guide the DNA "vehicle" selectively accumulating in the cancer cells in a detectable manner. More importantly, Cy5.5 showed reactive oxygen species (ROS) generation ability, which made it a promising adjuvant chemotherapy amplifier for cancer theranostics.

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