Binding Reaction Sites to Polysiloxanes: Unique Fluorescent Probe for Reversible Detection of ClO–/GSH Pair and the in Situ Imaging in Live Cells and Zebrafish | Zendy

Yujing Zuo | Zendy; Yu Zhang | Zendy; Baoli Dong | Zendy; Zhiming Gou | Zendy; Tingxin Yang | Zendy; Weiying Lin | Zendy

Open Access

Binding Reaction Sites to Polysiloxanes: Unique Fluorescent Probe for Reversible Detection of ClO^–/GSH Pair and the in Situ Imaging in Live Cells and Zebrafish

Author(s) -

Yujing Zuo,

Yu Zhang,

Baoli Dong,

Zhiming Gou,

Tingxin Yang,

Weiying Lin

Publication year - 2019

Publication title -

analytical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.117

H-Index - 332

eISSN - 1520-6882

pISSN - 0003-2700

DOI - 10.1021/acs.analchem.8b05465

Subject(s) - chemistry , fluorescence , zebrafish , in situ , live cell imaging , biocompatible material , nanotechnology , fluorescence microscope , in vivo , luminescence , glutathione , biosensor , biophysics , combinatorial chemistry , biochemistry , organic chemistry , cell , biomedical engineering , materials science , optoelectronics , medicine , microbiology and biotechnology , quantum mechanics , enzyme , physics , biology , gene

PDMS is biocompatible, economically viable, transparent, and facile to handle and thus is suitable for fluorescent microscopy and biological research. However, there has been no report about polysiloxane-based fluorescent probes applied in bioimaging. In this report, a two-photon polysiloxane-based reversible luminescent probe (P1) was fabricated for the first time. P1 is a powerful tool for detecting the ClO - /GSH cycle in situ both in live cells and in zebrafish. This work demonstrates the potential of polysiloxane-based fluorescent probes for versatile in vivo or in vitro applications in the future.

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