Tracking of Mitochondrial Endogenous Ribonucleic Acid in the Cancer Cells and Macrophages Using a Novel Small-Molecular Fluorescent Probe | Zendy

Yong Liu | Zendy; Jie Niu | Zendy; Weishan Wang | Zendy; Weiying Lin | Zendy

Open Access

Tracking of Mitochondrial Endogenous Ribonucleic Acid in the Cancer Cells and Macrophages Using a Novel Small-Molecular Fluorescent Probe

Author(s) -

Yong Liu,

Jie Niu,

Weishan Wang,

Weiying Lin

Publication year - 2019

Publication title -

analytical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.117

H-Index - 332

eISSN - 1520-6882

pISSN - 0003-2700

DOI - 10.1021/acs.analchem.8b05305

Subject(s) - chemistry , endogeny , fluorescence , rna , mitochondrion , cancer cell , biophysics , biochemistry , cancer , microbiology and biotechnology , gene , genetics , physics , quantum mechanics , biology

The expression of the genetic information on protein is achieved by mitochondrial RNA (mtRNA). However, mtRNA tracking in biological systems is bound due to the lack of an effective method. To solve this pressing problem, we construct a low molecular weight probe MR-IDE to track endogenous mtRNA in the cancer cells and macrophages for the first time.

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