Redox Capacitive Assaying of C-Reactive Protein at a Peptide Supported Aptamer Interface | Zendy

Julia P. Piccoli | Zendy; Robert Hein | Zendy; Afaf H. ElSagheer | Zendy; Tom Brown | Zendy; Eduardo Maffud Cilli | Zendy; Paulo R. Bueno | Zendy; Jason J. Davis | Zendy

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Redox Capacitive Assaying of C-Reactive Protein at a Peptide Supported Aptamer Interface

Author(s) -

Julia P. Piccoli,

Robert Hein,

Afaf H. ElSagheer,

Tom Brown,

Eduardo Maffud Cilli,

Paulo R. Bueno,

Jason J. Davis

Publication year - 2018

Publication title -

analytical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.117

H-Index - 332

eISSN - 1520-6882

pISSN - 0003-2700

DOI - 10.1021/acs.analchem.7b05374

Subject(s) - chemistry , aptamer , peptide , redox , interface (matter) , combinatorial chemistry , nanotechnology , biochemistry , microbiology and biotechnology , inorganic chemistry , materials science , biology , pulmonary surfactant , gibbs isotherm

Electrochemical immunosensors offer much in the potential translation of a lab based sensing capability to a useful "real world" platform. In previous work we have introduced an impedance-derived electrochemical capacitance spectroscopic analysis as supportive of a reagentless means of reporting on analyte target capture at suitably prepared mixed-component redox-active, antibody-modified interfaces. Herein we directly integrate receptive aptamers into a redox charging peptide support in enabling a label-free low picomolar analytical assay for C-reactive protein with a sensitivity that significantly exceeds that attainable with an analogous antibody interface.

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