Aptamer-Decorated Self-Assembled Aggregation-Induced Emission Organic Dots for Cancer Cell Targeting and Imaging | Zendy

Pengfei Zhang | Zendy; Zheng Zhao | Zendy; Chuansheng Li | Zendy; Huifang Su | Zendy; Yayun Wu | Zendy; Ryan T. K. Kwok | Zendy; Jacky W. Y. Lam | Zendy; Ping Gong | Zendy; Lintao Cai | Zendy; Ben Zhong Tang | Zendy

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Aptamer-Decorated Self-Assembled Aggregation-Induced Emission Organic Dots for Cancer Cell Targeting and Imaging

Author(s) -

Pengfei Zhang,

Zheng Zhao,

Chuansheng Li,

Huifang Su,

Yayun Wu,

Ryan T. K. Kwok,

Jacky W. Y. Lam,

Ping Gong,

Lintao Cai,

Ben Zhong Tang

Publication year - 2017

Publication title -

analytical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.117

H-Index - 332

eISSN - 1520-6882

pISSN - 0003-2700

DOI - 10.1021/acs.analchem.7b03933

Subject(s) - aptamer , aggregation induced emission , chemistry , nanodot , nanotechnology , biocompatibility , fluorescence , brightness , quantum dot , materials science , microbiology and biotechnology , organic chemistry , physics , quantum mechanics , optics , biology

A facile and simple one-step method was developed to fabricate aptamer-decorated self-assembled organic dots with aggregation-induced emission (AIE) characteristics. With integration of the advantages of AIE aggregates with strong emission and the cell-targeting capability of aptamers, the as-prepared Apt-AIE organic nanodots can specifically target to cancer cells with good biocompatibility, high image constrast, and photostability. On the basis of this universal method, a variety of versatile organic fluorescent nanoprobes with high brightness, specific recognition, and clinical-transitional potential could be facilely constructed for biological sensing and imaging applications.

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