Biological Contamination of Nanoparticles and Its Manifestation in Optical Absorbance Measurements | Zendy

Yuriy Garbovskiy | Zendy

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Biological Contamination of Nanoparticles and Its Manifestation in Optical Absorbance Measurements

Author(s) -

Yuriy Garbovskiy

Publication year - 2017

Publication title -

analytical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.117

H-Index - 332

eISSN - 1520-6882

pISSN - 0003-2700

DOI - 10.1021/acs.analchem.7b01766

Subject(s) - absorbance , chemistry , chromogenic , contamination , nanoparticle , nanomaterials , nanotechnology , optical sensing , chromatography , optoelectronics , materials science , ecology , biology

The biological contamination of nanomaterials is a serious problem hampering their widespread use in biomedical products. Existing commercial chromogenic assays for the detection and quantification of biocontaminants such as endotoxin can interfere with nanoparticles thus leading to unreliable data. The results reported in this Letter offer a solution to the aforementioned problems of the nanoparticle interference and correct quantification of biocontaminants by decomposing their optical absorbance into two physically measurable components and analyzing them as a function of the concentration of contaminated nanoparticles.

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