Tandem Mass Spectrometry in Combination with Product Ion Mobility for the Identification of Phospholipids | Zendy

Karin A. Zemski Berry | Zendy; Robert M. Barkley | Zendy; Joseph J. Berry | Zendy; Joseph A. Hankin | Zendy; Emmy Hoyes | Zendy; Jeffery M. Brown | Zendy; Robert C. Murphy | Zendy

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Tandem Mass Spectrometry in Combination with Product Ion Mobility for the Identification of Phospholipids

Author(s) -

Karin A. Zemski Berry,

Robert M. Barkley,

Joseph J. Berry,

Joseph A. Hankin,

Emmy Hoyes,

Jeffery M. Brown,

Robert C. Murphy

Publication year - 2016

Publication title -

analytical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.117

H-Index - 332

eISSN - 1520-6882

pISSN - 0003-2700

DOI - 10.1021/acs.analchem.6b04047

Subject(s) - chemistry , ion mobility spectrometry , ion , tandem mass spectrometry , mass spectrometry , lipidomics , tandem , top down proteomics , analytical chemistry (journal) , chromatography , selected reaction monitoring , biochemistry , organic chemistry , materials science , composite material

Concerted tandem and traveling wave ion mobility mass spectrometry (CTS analysis) is a unique method that results in a four-dimensional data set including nominal precursor ion mass, product ion mobility, accurate mass of product ion, and ion abundance. This nontargeted lipidomics CTS approach was applied in both positive- and negative-ion mode to phospholipids present in human serum, and the data set was used to evaluate the value of product ion mobility in identifying lipids in a complex mixture. It was determined that the combination of diagnostic product ions and unique collisional cross-section values of product ions is a powerful tool in the structural identification of lipids in a complex biological sample.

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