In Situ Ion-Transmission Mass Spectrometry for Paper-Based Analytical Devices | Zendy

Yaoyao Zhao | Zendy; Zhenwei Wei | Zendy; Hansen Zhao | Zendy; Jia Jia | Zendy; Zhenzhen Chen | Zendy; Sichun Zhang | Zendy; Zheng Ouyang | Zendy; Xiaoxiao Ma | Zendy; Xinrong Zhang | Zendy

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In Situ Ion-Transmission Mass Spectrometry for Paper-Based Analytical Devices

Author(s) -

Yaoyao Zhao,

Zhenwei Wei,

Hansen Zhao,

Jia Jia,

Zhenzhen Chen,

Sichun Zhang,

Zheng Ouyang,

Xiaoxiao Ma,

Xinrong Zhang

Publication year - 2016

Publication title -

analytical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.117

H-Index - 332

eISSN - 1520-6882

pISSN - 0003-2700

DOI - 10.1021/acs.analchem.6b03272

Subject(s) - analyte , chemistry , mass spectrometry , analytical chemistry (journal) , ion mobility spectrometry , chromatography , sample preparation , in situ , ion , ion current , sample (material) , organic chemistry

Current detection methods for paper-based analytical devices (PADs) rely on spectroscopic and electrochemical properties, which place special requirements on the analyte or need analyte labeling. Here, ion-transmission mass spectrometry (MS) was proposed for coupling with PADs to enable rapid in situ MS analysis of the sample on paper. The sample was analyzed directly on paper via analyte ionization by ions transmitted through the paper, generated by a low-temperature plasma probe. Prior to MS analysis, the sample can be separated by paper electrophoresis or by paper chromatography, among a variety of other features offered by PADs. The versatility of this technique was demonstrated by MS analysis of a paper microarray, a mixture of amino acids, and whole blood doped with drugs on PADs.

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