Open AccessMobility-Selected Ion Trapping and Enrichment Using Structures for Lossless Ion Manipulations
Author(s) -
Tsung-Chi Chen,
Yehia Ibrahim,
Ian Webb,
Sandilya Garimella,
Xing Zhang,
Ahmed Hamid,
Linhua Deng,
William E. Karnesky,
Spencer Prost,
Jeremy Sandoval,
Randolph V. Norheim,
Gordon A. Anderson,
Aleksey V. Tolmachev,
Erin Baker,
Richard Smith
Publication year - 2016
Publication title -
analytical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.117
H-Index - 332
eISSN - 1520-6882
pISSN - 0003-2700
DOI - 10.1021/acs.analchem.5b03910
Subject(s) - chemistry , trapping , ion , ion trap , ion trapping , ion mobility spectrometry , mass spectrometry , trap (plumbing) , quadrupole ion trap , analytical chemistry (journal) , sensitivity (control systems) , abundance (ecology) , chromatography , physics , ecology , organic chemistry , fishery , meteorology , biology , electronic engineering , engineering
The integration of ion mobility spectrometry (IMS) with mass spectrometry (MS) and the ability to trap ions in IMS-MS measurements is of great importance for performing reactions, accumulating ions, and increasing analytical measurement sensitivity. The development of Structures for Lossless Ion Manipulations (SLIM) offers the potential for ion manipulations in an extended and more effective manner, while opening opportunities for many more complex sequences of manipulations. Here, we demonstrate an ion separation and trapping module and a method based upon SLIM that consists of a linear mobility ion drift region, a switch/tee and a trapping region that allows the isolation and accumulation of mobility-separated species. The operation and optimization of the SLIM switch/tee and trap are described and demonstrated for the enrichment of the low abundance ions. A linear improvement in ion intensity was observed with the number of trapping/accumulation events using the SLIM trap, illustrating its potential for enhancing the sensitivity of low abundance or targeted species.