Visualizing Fluoride Ion in Mitochondria and Lysosome of Living Cells and in Living Mice with Positively Charged Ratiometric Probes | Zendy

Zhisheng Wu | Zendy; Xinjing Tang | Zendy

Open Access

Visualizing Fluoride Ion in Mitochondria and Lysosome of Living Cells and in Living Mice with Positively Charged Ratiometric Probes

Author(s) -

Zhisheng Wu,

Xinjing Tang

Publication year - 2015

Publication title -

analytical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.117

H-Index - 332

eISSN - 1520-6882

pISSN - 0003-2700

DOI - 10.1021/acs.analchem.5b02578

Subject(s) - chemistry , fluoride , lysosome , ion , mitochondrion , fluorescence , biophysics , in vivo , biochemistry , inorganic chemistry , enzyme , organic chemistry , optics , physics , microbiology and biotechnology , biology

Two ratiometric probes fluoride ion, Mito-F and Lyso-F, were rationally designed and synthesized with positive charges at physiological conditions. The positive charges functioned as target moieties for subcellular mitochondria and lysosome of living cells, and effective sequesters of fluoride ion for fast and efficient fluorescent detection. In addition, in vivo imaging of fluoride ion in living mice was successfully achieved for the first time using probe Mito-F.

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