Simple Targeted Assays for Metabolic Pathways and Signaling: A Powerful Tool for Targeted Proteomics | Zendy

Dominik Kopczynski | Zendy; Andreas Hentschel | Zendy; Cristina Coman | Zendy; Nils Helge Schebb | Zendy; Thorsten Hornemann | Zendy; Douglas G. Mashek | Zendy; Nicole M. Hartung | Zendy; Olga Shevchuk | Zendy; Hans-Frieder Schött | Zendy; Kristina Lorenz | Zendy; Federico Torta | Zendy; Bo Burla | Zendy; René P. Zahedi | Zendy; Albert Sickmann | Zendy; Michael R. Kreutz | Zendy; Christer S. Ejsing | Zendy; Jan Medenbach | Zendy; Robert Ahrends | Zendy

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Simple Targeted Assays for Metabolic Pathways and Signaling: A Powerful Tool for Targeted Proteomics

Author(s) -

Dominik Kopczynski,

Andreas Hentschel,

Cristina Coman,

Nils Helge Schebb,

Thorsten Hornemann,

Douglas G. Mashek,

Nicole M. Hartung,

Olga Shevchuk,

Hans-Frieder Schött,

Kristina Lorenz,

Federico Torta,

Bo Burla,

René P. Zahedi,

Albert Sickmann,

Michael R. Kreutz,

Christer S. Ejsing,

Jan Medenbach,

Robert Ahrends

Publication year - 2020

Publication title -

analytical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.117

H-Index - 332

eISSN - 1520-6882

pISSN - 0003-2700

DOI - 10.1021/acs.analchem.0c02793

Subject(s) - proteomics , chemistry , computational biology , signal transduction , metabolic pathway , biochemistry , biology , enzyme , gene

We introduce STAMPS, a pathway-centric web service for the development of targeted proteomics assays. STAMPS guides the user by providing several intuitive interfaces for a rapid and simplified method design. Applying our curated framework to signaling and metabolic pathways, we reduced the average assay development time by a factor of ∼150 and revealed that the insulin signaling is actively controlled by protein abundance changes in insulin-sensitive and -resistance states. Although at the current state STAMPS primarily contains mouse data, it was designed for easy extension with additional organisms.

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