Microfluidic Immunoassays for Sensitive and Simultaneous Detection of IgG/IgM/Antigen of SARS-CoV-2 within 15 min | Zendy

Qiuyuan Lin | Zendy; Donghua Wen | Zendy; Jing Wu | Zendy; Liling Liu | Zendy; Wenjuan Wu | Zendy; Xueen Fang | Zendy; Jilie Kong | Zendy

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Microfluidic Immunoassays for Sensitive and Simultaneous Detection of IgG/IgM/Antigen of SARS-CoV-2 within 15 min

Author(s) -

Qiuyuan Lin,

Donghua Wen,

Jing Wu,

Liling Liu,

Wenjuan Wu,

Xueen Fang,

Jilie Kong

Publication year - 2020

Publication title -

analytical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.117

H-Index - 332

eISSN - 1520-6882

pISSN - 0003-2700

DOI - 10.1021/acs.analchem.0c01635

Subject(s) - immunoassay , antigen , antibody , covid-19 , chemistry , virology , outbreak , immunoglobulin g , immunology , medicine , infectious disease (medical specialty) , disease

The outbreak of SARS-CoV-2 is posing serious global public health problems. Facing the emergence of this pandemic, we established a portable microfluidic immunoassay system for easy-to-use, sensitive, rapid (<15 min), multiple, and on-site detection of IgG/IgM/Antigen of SARS-CoV-2 simultaneously. This integrated method was successfully applied for detecting SARS-CoV-2 IgM and IgG antibodies in clinical human serum as well as SARS-CoV-2 antigen in pharyngeal swabs from 26 patients with COVID-19 infection and 28 uninfected people. The assay demonstrated high sensitivity and specificity, which is promising for the diagnosis and monitoring as well as control of SARS-CoV-2 worldwide.

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