A Barcode-Free Combinatorial Screening Platform for Matrix Metalloproteinase Screening | Zendy

Tushar D. Rane | Zendy; Helena C. Zec | Zendy; TzaHuei Wang | Zendy

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A Barcode-Free Combinatorial Screening Platform for Matrix Metalloproteinase Screening

Author(s) -

Tushar D. Rane,

Helena C. Zec,

TzaHuei Wang

Publication year - 2014

Publication title -

analytical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.117

H-Index - 332

eISSN - 1520-6882

pISSN - 0003-2700

DOI - 10.1021/ac504330x

Subject(s) - barcode , microfluidics , chemistry , matrix (chemical analysis) , nanotechnology , computational biology , chromatography , computer science , materials science , biology , operating system

Application of droplet microfluidics to combinatorial screening applications remains elusive because of the need for composition-identifying unique barcodes. Here we propose a barcode-free continuous flow droplet microfluidic platform to suit the requirements of combinatorial screening applications. We demonstrate robust and repeatable functioning of this platform with matrix metalloproteinase activity screening as a sample application.

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