Mass Spectrometric Detection of Nanoparticle Host–Guest Interactions in Cells | Zendy

Bo Yan | Zendy; Gülen Yesilbag Tonga | Zendy; Singyuk Hou | Zendy; Patrick W. Fedick | Zendy; YiCheun Yeh | Zendy; Felix S. Alfonso | Zendy; Tsukasa Mizuhara | Zendy; Richard W. Vachet | Zendy; Vincent M. Rotello | Zendy

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Mass Spectrometric Detection of Nanoparticle Host–Guest Interactions in Cells

Author(s) -

Bo Yan,

Gülen Yesilbag Tonga,

Singyuk Hou,

Patrick W. Fedick,

YiCheun Yeh,

Felix S. Alfonso,

Tsukasa Mizuhara,

Richard W. Vachet,

Vincent M. Rotello

Publication year - 2014

Publication title -

analytical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.117

H-Index - 332

eISSN - 1520-6882

pISSN - 0003-2700

DOI - 10.1021/ac501682y

Subject(s) - chemistry , mass spectrometry , nanoparticle , dissociation (chemistry) , ionization , nanotechnology , host (biology) , characterization (materials science) , matrix assisted laser desorption/ionization , desorption , chromatography , ion , organic chemistry , adsorption , ecology , materials science , biology

Synthetic host-guest chemistry is a versatile tool for biomedical applications. Characterization and detection of host-guest complexes in biological systems, however, is challenging due to the complexity of the biological milieu. Here, we describe and apply a mass spectrometric method to monitor the association and dissociation of nanoparticle (NP)-based host-guest interactions that integrates NP-assisted laser desorption/ionization (LDI) and matrix assisted laser desoption/ionization (MALDI) mass spectrometry. This LDI/MALDI approach reveals how NP surface functionality affects host-guest interactions in cells, information difficult to achieve using other techniques.

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