Glycan based Detection and Drug Susceptibility of Influenza Virus | Zendy

Hieu Dinh | Zendy; Xiaohu Zhang | Zendy; Joyce Sweeney | Zendy; Yang Yang | Zendy; Yun He | Zendy; Abasaheb N. Dhawane | Zendy; Suri S. Iyer | Zendy

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Glycan based Detection and Drug Susceptibility of Influenza Virus

Author(s) -

Hieu Dinh,

Xiaohu Zhang,

Joyce Sweeney,

Yang Yang,

Yun He,

Abasaheb N. Dhawane,

Suri S. Iyer

Publication year - 2014

Publication title -

analytical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.117

H-Index - 332

eISSN - 1520-6882

pISSN - 0003-2700

DOI - 10.1021/ac501624v

Subject(s) - chemistry , glycan , virus , zanamivir , microarray , virology , influenza a virus , detection limit , drug resistance , drug , microbiology and biotechnology , chromatography , gene , glycoprotein , biology , biochemistry , covid-19 , pharmacology , infectious disease (medical specialty) , medicine , gene expression , disease , pathology

We have developed a panel of synthetic glycans as receptor mimics for the specific capture of influenza viruses. The glycans were printed onto commercial glass slides using a free amine at the end of a spacer to generate a small focused microarray. The microarray was evaluated for its ability to capture three different strains of influenza A virus, two H1N1, A/Brisbane/59/2007 and A/Solomon Islands/3/2006 and one H3N2, A/Aichi/2/1968. We observed an excellent detection ability with some compounds exhibiting clinically relevant (10(1) plaque forming units) limit of detection. We also tested the drug susceptibility of current antivirals, Zanamivir and Ostelamivir using this microarray and could determine antiviral resistance for these strains.

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