Cysteine-Cystine Redox Cycling in a Gold–Gold Dual-Plate Generator-Collector Microtrench Sensor | Zendy

Jules L. Hammond | Zendy; Andrew J. Gross | Zendy; Pedro Estrela | Zendy; Jesús Iniesta | Zendy; Stephen J. Green | Zendy; C.P. Winlove | Zendy; Paul G. Winyard | Zendy; Nigel Benjamin | Zendy; Frank Marken | Zendy

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Cysteine-Cystine Redox Cycling in a Gold–Gold Dual-Plate Generator-Collector Microtrench Sensor

Author(s) -

Jules L. Hammond,

Andrew J. Gross,

Pedro Estrela,

Jesús Iniesta,

Stephen J. Green,

C.P. Winlove,

Paul G. Winyard,

Nigel Benjamin,

Frank Marken

Publication year - 2014

Publication title -

analytical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.117

H-Index - 332

eISSN - 1520-6882

pISSN - 0003-2700

DOI - 10.1021/ac501321e

Subject(s) - chemistry , cystine , redox , cysteine , electrode , adsorption , inorganic chemistry , organic chemistry , enzyme

Thiols and disulfides are ubiquitous and important analytical targets. However, their redox properties, in particular on gold sensor electrodes, are complex and obscured by strong adsorption. Here, a gold-gold dual-plate microtrench dual-electrode sensor with feedback signal amplification is demonstrated to give well-defined (but kinetically limited) steady-state voltammetric current responses for the cysteine-cystine redox cycle in nondegassed aqueous buffer media at pH 7 down to micromolar concentration levels.

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