Nanoliter Segmented-Flow Sampling Mass Spectrometry with Online Compartmentalization | Zendy

Michael Volný | Zendy; Joelle Rolfs | Zendy; Bejan Hakimi | Zendy; Petr Fryčák | Zendy; Thomas Schneider | Zendy; Dingsheng Liu | Zendy; Gloria S. Yen | Zendy; Daniel T. Chiu | Zendy; František Tureček | Zendy

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Nanoliter Segmented-Flow Sampling Mass Spectrometry with Online Compartmentalization

Author(s) -

Michael Volný,

Joelle Rolfs,

Bejan Hakimi,

Petr Fryčák,

Thomas Schneider,

Dingsheng Liu,

Gloria S. Yen,

Daniel T. Chiu,

František Tureček

Publication year - 2014

Publication title -

analytical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.117

H-Index - 332

eISSN - 1520-6882

pISSN - 0003-2700

DOI - 10.1021/ac500365r

Subject(s) - chemistry , mass spectrometry , analytical chemistry (journal) , analyte , microfluidics , ionization , chromatography , spectrometer , sample preparation , nanotechnology , optics , ion , materials science , physics , organic chemistry

We report a microfluidic device, using segmented flow in a two-phase system of immiscible liquids, which delivers aqueous droplets into a modified commercial mass spectrometer. The interface coupling the microfluidics to the mass spectrometer achieves up to 96% sample transfer efficiency to the vacuum chamber. Sample ionization is assisted by multipass infrared laser beam in the interface. The system achieves low femtomole detection limits of several analytes ranging from drugs to proteins. Sample ionization in this segmented-flow sampling was found to be remarkably insensitive to the presence of buffer salts and other matrices.

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