Three Dimensional Microfluidic Cell Arrays for ex Vivo Drug Screening with Mimicked Vascular Flow | Zendy

Zeynep DereliKorkut | Zendy; H. Dogus Akaydin | Zendy; A. H. Rezwanuddin Ahmed | Zendy; Xuejun Jiang | Zendy; Sihong Wang | Zendy

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Three Dimensional Microfluidic Cell Arrays for ex Vivo Drug Screening with Mimicked Vascular Flow

Author(s) -

Zeynep DereliKorkut,

H. Dogus Akaydin,

A. H. Rezwanuddin Ahmed,

Xuejun Jiang,

Sihong Wang

Publication year - 2014

Publication title -

analytical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.117

H-Index - 332

eISSN - 1520-6882

pISSN - 0003-2700

DOI - 10.1021/ac403899j

Subject(s) - ex vivo , polydimethylsiloxane , in vivo , chemistry , microfluidics , tumor microenvironment , extracellular matrix , drug delivery , biomedical engineering , cancer cell , nanotechnology , cancer , cancer research , tumor cells , in vitro , biology , materials science , biochemistry , medicine , microbiology and biotechnology , organic chemistry

Currently, there are no reliable ex vivo models that predict anticancer drug responses in human tumors accurately. A comprehensive method of mimicking a 3D microenvironment to study effects of anticancer drugs on specific cancer types is essential. Here, we report the development of a three-dimensional microfluidic cell array (3D μFCA), which reconstructs a 3D tumor microenvironment with cancer cells and microvascular endothelial cells. To mimic the in vivo spatial relationship between microvessels and nonendothelial cells embedded in extracellular matrix, three polydimethylsiloxane (PDMS) layers were built into this array. The multilayer property of the device enabled the imitation of the drug delivery in a microtissue array with simulated blood circulation. This 3D μFCA system may provide better predictions of drug responses and identification of a suitable treatment for a specific patient if biopsy samples are used. To the pharmaceutical industry, the scaling-up of our 3D μFCA system may offer a novel high throughput screening tool.

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