Transcutaneous Glucose Sensing by Surface-Enhanced Spatially Offset Raman Spectroscopy in a Rat Model | Zendy

Jonathan M. Yuen | Zendy; Nilam C. Shah | Zendy; Joseph T. Walsh | Zendy; Matthew R. Glucksberg | Zendy; Richard P. Van Duyne | Zendy

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Transcutaneous Glucose Sensing by Surface-Enhanced Spatially Offset Raman Spectroscopy in a Rat Model

Author(s) -

Jonathan M. Yuen,

Nilam C. Shah,

Joseph T. Walsh,

Matthew R. Glucksberg,

Richard P. Van Duyne

Publication year - 2010

Publication title -

analytical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.117

H-Index - 332

eISSN - 1520-6882

pISSN - 0003-2700

DOI - 10.1021/ac101951j

Subject(s) - chemistry , raman spectroscopy , monolayer , surface enhanced raman spectroscopy , in vivo , spectroscopy , analytical chemistry (journal) , nanotechnology , raman scattering , chromatography , optics , biochemistry , materials science , physics , microbiology and biotechnology , quantum mechanics , biology

This letter presents the first quantitative, in vivo, transcutaneous glucose measurements using surface enhanced Raman spectroscopy (SERS). Silver film over nanosphere (AgFON) surfaces were functionalized with a mixed self-assembled monolayer (SAM) and implanted subcutaneously in a Sprague-Dawley rat. The glucose concentration was monitored in the interstitial fluid. SER spectra were collected from the sensor chip through the skin using spatially offset Raman spectroscopy (SORS). The combination of SERS and SORS is a powerful new approach to the challenging problem of in vivo metabolite and drug sensing.

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