Open AccessInsulin effects on myocardial function and bioenergetics in l-bupivacaine toxicity in the isolated rat heart
Author(s) -
Sebastian Stehr,
Annette Pexa,
S. Hannack,
A. Heintz,
Axel R. Heller,
Andreas Deußen,
Thea Koch,
Matthias Hübler
Publication year - 2007
Publication title -
european journal of anaesthesiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 76
eISSN - 1365-2346
pISSN - 0265-0215
DOI - 10.1017/s0265021506002109
Subject(s) - medicine , bupivacaine , heart rate , insulin , rate pressure product , inotrope , ventricular pressure , blood pressure , endocrinology , cardiology , anesthesia
A positive effect of insulin-glucose-potassium infusion in severe bupivacaine-induced cardiovascular collapse has been described in vivo. It has been speculated that an antagonistic influence of insulin on sodium channel inhibition, transient outward potassium current, calcium-dependent adenosine triphosphatase or even improved myocardial energetics may be responsible for this effect. Using an isolated heart model, we therefore sought to further elucidate insulin effects in l-bupivacaine-induced myocardial depression.