Open AccessAdenosine A1 and A2 receptor agonists reduce endotoxin-induced cellular energy depletion and oedema formation in the lung
Author(s) -
Axel R. Heller,
Juliane Rothermel,
Markus A. Weigand,
Konstanze Plaschke,
Joachim Schmeck,
Martina Wendel,
Hubert J. Bardenheuer,
Thea Koch
Publication year - 2007
Publication title -
european journal of anaesthesiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 76
eISSN - 1365-2346
pISSN - 0265-0215
DOI - 10.1017/s026502150600144x
Subject(s) - adenosine , agonist , medicine , adenosine a1 receptor , endocrinology , ccpa , adenosine monophosphate , adenine nucleotide , lung , adenosine receptor , receptor , biochemistry , chemistry , nucleotide , gene
Tissue depletion of adenosine during endotoxaemia has previously been described in the lung. Therapeutic approaches to prevent adenosine depletion and the role of A1 and A2 receptor agonists, however, have not been investigated until now.