Open AccessA simple approach for coupling liquid chromatography and electron ionization mass spectrometry
Author(s) -
Achille Cappiello,
Giorgio Famiglini,
Filippo Mangani,
Pierangela Palma
Publication year - 2002
Publication title -
journal of the american society for mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.961
H-Index - 127
eISSN - 1879-1123
pISSN - 1044-0305
DOI - 10.1016/s1044-0305(01)00363-4
Subject(s) - chemistry , mass spectrometry , direct electron ionization liquid chromatography–mass spectrometry interface , electron ionization , analytical chemistry (journal) , chromatography , ionization , mass spectrum , chemical ionization , atmospheric pressure chemical ionization , ion , organic chemistry
A miniaturized, aerosol based interface for directly coupling a liquid chromatograph with a mass spectrometer is presented. The interface is entirely within the electron ionization (EI) source of the mass spectrometer and no additional, external devices are needed. This simple and effective approach exploits micro-flow nebulization technology providing a new interface suitable for a variety of applications of environmental and biological interest. The new interface provides necessary linearity, ruggedness, sensitivity, and reproducibility of response for trace level analysis, and readily interpretable mass spectra for unambiguous identification of unknown compounds of small to medium molecular weight.