Open AccessAdenoviral gene transfer to the heart during cardiopulmonary bypass: effect of myocardial protection technique on transgene expression
Author(s) -
J M Jones,
Katrina H. Wilson,
Walter J. Koch,
Carmelo A. Milano
Publication year - 2002
Publication title -
european journal of cardio-thoracic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.303
H-Index - 133
eISSN - 1873-734X
pISSN - 1010-7940
DOI - 10.1016/s1010-7940(02)00078-7
Subject(s) - cardiopulmonary bypass , transgene , hypothermia , ventricular fibrillation , medicine , cardiology , anesthesia , chemistry , gene , biochemistry
Adenoviral gene transfer to the arrested heart during cardiopulmonary bypass (CPB) is a novel method of allowing prolonged vector contact with the myocardium. In this model we investigated the importance of temperature, duration of arrest and cardioplegia on transgene expression.
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