Open AccessAvian HSC emergence, migration, and commitment toward the T cell lineage
Author(s) -
Jaffredo Thierry,
Alais Sandrine,
Bollerot Karine,
Drevon Cecile,
Gautier Rodolphe,
Guezguez Borhane,
Minko Krisztina,
Vigneron Pascale,
Du Dominique
Publication year - 2003
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1016/s0928-8244(03)00295-5
Subject(s) - biology , allantois , haematopoiesis , yolk sac , lineage (genetic) , microbiology and biotechnology , stem cell , evolutionary biology , immunology , embryo , genetics , gene
To date three sites of emergence of hemopoietic cells have been identified during early avian development: the yolk sac, the intraaortic clusters and recently the allantois. However, the contributions of the hematopoietic stem cell (HSC) populations generated by these different sites to definitive hematopoiesis and their migration routes are not fully unraveled. Experimental embryology as well as the establishment of the genetic cascades involved in HSC emergence help now to draw a better scheme of these processes.