Open AccessEscherichia coli bind to urinary bladder epithelium through nonspecific sialic acid mediated adherence
Author(s) -
Sakarya Serhan,
Ertem Gunay Tuncer,
Oncu Serkan,
Kocak Izzet,
Erol Nural,
Oncu Selcan
Publication year - 2003
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1016/s0928-8244(03)00185-8
Subject(s) - fimbria , microbiology and biotechnology , escherichia coli , bacterial adhesin , glycoconjugate , biology , sialic acid , urinary system , enterobacteriaceae , epithelium , n acetylneuraminic acid , biochemistry , endocrinology , gene , genetics
The first step in the bacterial colonization and infection of uropathogenic Escherichia coli is adherence to uroepithelium. Over 80% of all urinary tract infections are caused by E. coli . Uropathogenic E. coli express several adherence factors including type 1 and P fimbriae, which mediate attachment to the uroepithelium through specific binding to different glycoconjugate receptors. We showed that P and type 1 fimbriae are not the sole adhesins on uropathogenic E. coli and sialic acid also mediates nonspecific bacterial adherence of uropathogenic E. coli and urinary bladder epithelium.