Open AccessUse of Bordetella bronchiseptica and Bordetella pertussis as live vaccines and vectors for heterologous antigens
Author(s) -
Stevenson Andrew,
Roberts Mark
Publication year - 2003
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1016/s0928-8244(03)00068-3
Subject(s) - bordetella bronchiseptica , bordetella pertussis , heterologous , biology , bordetella , microbiology and biotechnology , antigen , virology , bacteria , immunology , biochemistry , genetics , gene
Bordetella pertussis and Bordetella bronchiseptica are respiratory pathogens of humans and animals respectively. Unlike many bacteria, they are able to efficiently colonise healthy ciliated respiratory mucosa. This characteristic of Bordetella spp. can potentially be exploited to develop efficient live vaccines and vectors for delivery of heterologous antigens to the respiratory tract. Here we review the progress in this area.