Open AccessIsoniazid resistance of exponentially growing Mycobacterium smegmatis biofilm culture
Author(s) -
Teng Raymond,
Dick Thomas
Publication year - 2003
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1016/s0378-1097(03)00584-6
Subject(s) - isoniazid , mycobacterium smegmatis , microbiology and biotechnology , biofilm , bacilli , minimum inhibitory concentration , biology , antibiotics , mycobacterium , drug resistance , bacteria , mycobacterium tuberculosis , tuberculosis , medicine , genetics , pathology
Biofilm growth of Mycobacterium smegmatis was found to be unaffected at an isoniazid concentration that inhibited growth of planktonic bacilli (i.e. at isoniazid minimum inhibitory concentration=10 μg ml −1 ). Significant growth (50% of drug‐free control) of biofilms was observed at up to 40 μg ml −1 and the MIC for biofilm growth showed an increase to up to 80 μg ml −1 isoniazid. Thus, the biofilm growth modus appears to be a strategy for replicating bacilli to evade the onslaught of antibacterials.