Open AccessZebrafish‐ Mycobacterium marinum model for mycobacterial pathogenesis
Author(s) -
Prouty Michael G.,
Correa Nidia E.,
Barker Lucia P.,
Jagadeeswaran Pudur,
Klose Karl E.
Publication year - 2003
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1016/s0378-1097(03)00446-4
Subject(s) - zebrafish , mycobacterium marinum , danio , pathogenesis , biology , microbiology and biotechnology , pathogen , mycobacterium tuberculosis , mycobacterium , tuberculosis , disease , granuloma , human pathogen , immunology , pathology , genetics , gene , medicine , bacteria
We report here the development of a pathogenesis model utilizing Mycobacterium marinum infection of zebrafish ( Danio rerio ) for the study of mycobacterial disease. The zebrafish model mimics certain aspects of human tuberculosis, such as the formation of granuloma‐like lesions and the ability to establish either an acute or a chronic infection based upon inoculum. This model allows the genetics of mycobacterial disease to be studied in both pathogen and host.