Open AccessMolecular and biochemical analysis of the system regulating the lytic/lysogenic cycle in the pneumococcal temperate phage MM1
Author(s) -
Obregón Virginia,
Garcı́a Pedro,
López Rubens,
Garcı́a José L
Publication year - 2003
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1016/s0378-1097(03)00281-7
Subject(s) - lysogenic cycle , lytic cycle , lysogen , temperateness , biology , bacteriophage , microbiology and biotechnology , genetics , streptococcus pneumoniae , gene , bacteria , virus , escherichia coli
The temperate phage MM1 forms stable lysogens in Streptococcus pneumoniae . We report here the first characterization of the lysogenic control region in Pneumococcus which contains two functional divergent promoters (P R and P L ). MM1 encodes a 14‐kDa cI protein (CI) that appears to be responsible for maintaining the lysogenic state in Pneumococcus since it prevents elongation of the transcripts controlled by P R and P L .