Open AccessAllelic variation in srtA s of Streptococcus suis strains
Author(s) -
Osaki Makoto,
Takamatsu Daisuke,
Shimoji Yoshihiro,
Sekizaki Tsutomu
Publication year - 2003
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1016/s0378-1097(03)00058-2
Subject(s) - streptococcus suis , sortase , complementation , biology , genetics , sortase a , computational biology , gene , bacterial protein , virulence , phenotype
Streptococcus suis NCTC10234 possesses five srtA homologs: srtA encodes sortase, which anchors surface proteins with an LPXTG motif to the cell wall, while the functions of the other four homologs (the srtBCD cluster and srtE ) remain unknown. The genetic organization of the srtA region was found to be conserved in the 59 S. suis strains examined in this study. Although the srtA s in three of these strains showed strong sequence divergence, their functions were verified to be overlapping by genetic complementation, indicating the functional conservation of srtA s during the evolution of these strains. These results indicate the importance of an srtA ‐mediated cell wall sorting system for displaying proteins on the surface of S. suis .