Open AccessProduction of macrosphelide A by the mycoparasite Coniothyrium minitans
Author(s) -
McQuilken Mark P,
Gemmell Jacqueline,
Hill Robert A,
Whipps John M
Publication year - 2003
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1016/s0378-1097(02)01180-1
Subject(s) - sclerotium , sclerotinia sclerotiorum , biology , metabolite , antifungal , fungi imperfecti , biological pest control , microbiology and biotechnology , botany , biochemistry
Coniothyrium minitans , a mycoparasite of sclerotia of Sclerotinia sclerotiorum and Sclerotium cepivorum , produced four closely related metabolites inhibitory to fungal growth. The major metabolite, identified as macrosphelide A, had IG 50 values (the concentration of metabolite to inhibit growth by 50%) of 46.6 and 2.9 μg ml −1 against S. sclerotiorum and S. cepivorum , respectively. This is the first report of both antifungal activity due to macrosphelide A as well as isolation of macrosphelide A from C. minitans .