Open AccessEffects of inhibition of sarcoplasmic reticulum calcium uptake on contraction in myocytes isolated from failing human ventricle
Author(s) -
Kerry Davia,
C. S. L. Davies,
Siân E. Harding
Publication year - 1997
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1016/s0008-6363(96)00187-3
Subject(s) - thapsigargin , myocyte , medicine , contraction (grammar) , ventricle , endoplasmic reticulum , endocrinology , calcium , heart failure , cardiology , chemistry , biochemistry
There has been debate regarding the level of sarcoplasmic reticulum (SR) Ca2+ ATPase protein in heart failure. We have used the SR Ca2+ ATPase inhibitor thapsigargin to investigate the functional contribution of this uptake system to contraction and relaxation in myocytes from failing and non-failing human ventricle.