Open AccessRight ventricular hypertrophy and apoptosis after pulmonary artery banding: regulation of PKC isozymes
Author(s) -
Martin Braun,
Palma Szalai,
Ruth H. Strasser,
Mathias M. Borst
Publication year - 2003
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1016/s0008-6363(03)00470-x
Subject(s) - protein kinase c , pressure overload , isozyme , medicine , calcineurin , endocrinology , apoptosis , western blot , cytosol , biology , muscle hypertrophy , pkc alpha , angiotensin ii , ventricle , pulmonary artery , signal transduction , microbiology and biotechnology , enzyme , blood pressure , biochemistry , transplantation , cardiac hypertrophy , gene
Pressure overload induced by pulmonary artery banding (PAB) leads to right ventricular (RV) hypertrophy and cardiomyocyte apoptosis. The present study was performed to investigate whether protein kinase C isozymes (PKC-alpha, PKC-betaI, PKC-betaII, PKC-delta and PFC- epsilon ), calcineurin and the renin-angiotensin system (RAS) contribute to PAB-induced cardiac remodeling.