Tissue factor pathway inhibitor gene delivery using HVJ-AVE liposomes markedly reduces restenosis in atherosclerotic arteries | Zendy

Xinhua Yin | Zendy

Open Access

Tissue factor pathway inhibitor gene delivery using HVJ-AVE liposomes markedly reduces restenosis in atherosclerotic arteries

Author(s) -

Xinhua Yin

Publication year - 2002

Publication title -

cardiovascular research

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1016/s0008-6363(02)00595-3

Subject(s) - restenosis , tissue factor pathway inhibitor , medicine , angioplasty , genetic enhancement , tissue factor , stenosis , coagulation , gene delivery , liposome , cardiology , stent , biology , gene , biochemistry

Tissue factor pathway inhibitor (TFPI), as a primary inhibitor of TF-induced coagulation, reduces neointimal formation and luminal stenosis by inhibiting coagulation and thrombosis after vessel wall injury. Here, we investigated the effect of TFPI gene delivery with a HVJ-AVE liposome vector on restenosis in atherosclerotic arteries after angioplasty in rabbits. We also evaluated the safety of the novel gene therapeutic strategy to prevent restenosis.

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