Open AccessRemote preconditioning protects the heart by activating myocardial PKCε-isoform
Author(s) -
Sebastian Wolfrum
Publication year - 2002
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1016/s0008-6363(02)00408-x
Subject(s) - ischemic preconditioning , chelerythrine , protein kinase c , ischemia , cytosol , medicine , chemistry , endocrinology , cardiology , phosphorylation , biochemistry , enzyme
Myocardial protection can be achieved by brief ischemia-reperfusion of remote organs, a phenomenon described as remote preconditioning (RPC). Since the intracellular mechanisms of RPC are not known, we tested the hypothesis that RPC might activate myocardial PKCepsilon, an essential mediator of classical ischemic preconditioning. Furthermore, we tried to delineate the mechanisms by which RPC is transduced to the heart with respect to the possible contribution of kinins and neuronal reflexes.