Developmental changes in the functional characteristics and expression of voltage-gated K+ channel currents in rat aortic myocytes | Zendy

Andriy E. Belevych | Zendy

Open Access

Developmental changes in the functional characteristics and expression of voltage-gated K+ channel currents in rat aortic myocytes

Author(s) -

Andriy E. Belevych

Publication year - 2002

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1016/s0008-6363(02)00227-4

Subject(s) - myocyte , tetraethylammonium , charybdotoxin , thoracic aorta , aorta , contraction (grammar) , biophysics , anatomy , patch clamp , medicine , chemistry , electrophysiology , biology , potassium channel , potassium , organic chemistry

Active control of the arterial diameter by vascular smooth muscle is one of the principle mechanisms by which vessels adapt to a significant rise in blood pressure after birth. Although voltage-gated K+ (Kv) channels play an important role in the regulation of excitation-contraction coupling in arteries, very little is known about postnatal modification of Kv channels. We therefore investigated changes in the functional characteristics and expression of Kv channels in rat aortic myocytes (RAMs) during early postnatal development.

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