Open AccessSimvastatin reduces reperfusion injury by modulating nitric oxide synthase expression: an ex vivo study in isolated working rat hearts
Author(s) -
Pericle Di Napoli,
Alfonso Antonio Taccardi,
Alfredo Grilli,
Rita Spina,
Mario Felaco,
Antonio Barsotti,
Raffaele De Caterina
Publication year - 2001
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1016/s0008-6363(01)00306-6
Subject(s) - simvastatin , enos , cardioprotection , reperfusion injury , nitric oxide synthase , pharmacology , ischemia , nitric oxide , nitric oxide synthase type iii , ex vivo , extravasation , chemistry , endocrinology , medicine , biochemistry , immunology , in vitro
We tested the hypothesis of beneficial effects of the 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA)-reductase inhibitor simvastatin in a model of ischemia-reperfusion, and investigated potential mechanisms.