Leber hereditary optic neuropathy – Therapeutic challenges and early promise | Zendy

Patrick YuWaiMan | Zendy; Patrick F. Chinnery | Zendy

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Leber hereditary optic neuropathy – Therapeutic challenges and early promise

Author(s) -

Patrick YuWaiMan,

Patrick F. Chinnery

Publication year - 2011

Publication title -

taiwan journal of ophthalmology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.519

H-Index - 9

eISSN - 2211-5072

pISSN - 2211-5056

DOI - 10.1016/j.tjo.2011.09.001

Subject(s) - medicine , idebenone , optic neuropathy , blinding , mitochondrial dna , leber's hereditary optic neuropathy , pediatrics , population , ophthalmology , pathology , genetics , clinical trial , optic nerve , environmental health , biology , gene

Leber hereditary optic neuropathy (LHON) is the most common primary mitochondrial DNA (mtDNA) disorder in the general population. It is an important cause of severe, usually irreversible, visual loss among young adults with a peak age of onset in the second and third decades of life. Management is currently mostly supportive but recent developments in LHON research are pointing the way towards more effective treatments for this blinding mitochondrial disorder.

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