Retinoic acid signaling in heart development: Application in the differentiation of cardiovascular lineages from human pluripotent stem cells | Zendy

Alexandra Wiesinger | Zendy; Gerard J.J. Boink | Zendy; Vincent M. Christoffels | Zendy; Harsha D. Devalla | Zendy

Open Access

Retinoic acid signaling in heart development: Application in the differentiation of cardiovascular lineages from human pluripotent stem cells

Author(s) -

Alexandra Wiesinger,

Gerard J.J. Boink,

Vincent M. Christoffels,

Harsha D. Devalla

Publication year - 2021

Publication title -

stem cell reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.207

H-Index - 76

ISSN - 2213-6711

DOI - 10.1016/j.stemcr.2021.09.010

Subject(s) - biology , retinoic acid , induced pluripotent stem cell , heart development , stem cell , microbiology and biotechnology , cellular differentiation , progenitor cell , developmental biology , embryonic stem cell , genetics , cell culture , gene

Retinoic acid (RA) signaling plays an important role during heart development in establishing anteroposterior polarity, formation of inflow and outflow tract progenitors, and growth of the ventricular compact wall. RA is also utilized as a key ingredient in protocols designed for generating cardiac cell types from pluripotent stem cells (PSCs). This review discusses the role of RA in cardiogenesis, currently available protocols that employ RA for differentiation of various cardiovascular lineages, and plausible transcriptional mechanisms underlying this fate specification. These insights will inform further development of desired cardiac cell types from human PSCs and their application in preclinical and clinical research.

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