Hippocampal CA1 Somatostatin Interneurons Originate in the Embryonic MGE/POA | Zendy

Zeinab Asgarian | Zendy; Lorenza Magno | Zendy; Niki Ktena | Zendy; Kenneth D. Harris | Zendy; Nicoletta Kessaris | Zendy

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Hippocampal CA1 Somatostatin Interneurons Originate in the Embryonic MGE/POA

Author(s) -

Zeinab Asgarian,

Lorenza Magno,

Niki Ktena,

Kenneth D. Harris,

Nicoletta Kessaris

Publication year - 2019

Publication title -

stem cell reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.207

H-Index - 76

ISSN - 2213-6711

DOI - 10.1016/j.stemcr.2019.09.008

Subject(s) - biology , hippocampal formation , neuroepithelial cell , population , somatostatin , hippocampus , neuroscience , embryonic stem cell , genetics , gene , demography , sociology

Oriens lacunosum-moleculare (O-LM) interneurons constitute 40% of hippocampal interneurons expressing Somatostatin (SST). Recent evidence has indicated a dual origin for these cells in the medial and caudal ganglionic eminences (MGE and CGE), with expression of Htr3a as a distinguishing factor. This is strikingly different from cortical SST interneurons that have a single origin within the MGE/preoptic area (POA). We reassessed the origin of hippocampal SST interneurons using a range of genetic lineage-tracing mice combined with single-cell transcriptomic analysis. We find a common origin for all hippocampal SST interneurons in NKX2-1-expressing progenitors of the telencephalic neuroepithelium and an MGE/POA-like transcriptomic signature for all SST clusters. This suggests that functional heterogeneity within the SST CA1 population cannot be attributed to a differential MGE/CGE genetic origin.

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