Non-Cell-Autonomous Neurotoxicity in Parkinson’s Disease Mediated by Astroglial α-Synuclein | Zendy

MuhChyi Chai | Zendy; Jun Kohyama | Zendy

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Non-Cell-Autonomous Neurotoxicity in Parkinson’s Disease Mediated by Astroglial α-Synuclein

Author(s) -

MuhChyi Chai,

Jun Kohyama

Publication year - 2019

Publication title -

stem cell reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.207

H-Index - 76

ISSN - 2213-6711

DOI - 10.1016/j.stemcr.2019.01.011

Subject(s) - biology , parkinson's disease , neuroscience , neurotoxicity , dopaminergic , disease , pathogenesis , cell , dopamine , immunology , pathology , toxicity , medicine , genetics

Non-cell-autonomous effects on neuronal cells are considered to be involved in the pathogenesis of neurodegenerative diseases but have yet to be mechanistically proven. In this issue of Stem Cell Reports, di Domenico et al. provide direct evidence that α-synuclein transferred from astrocytes exerts non-cell-autonomous neuronal dysfunction on dopaminergic neurons in Parkinson's disease (PD).

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