Cost-effectiveness of varicella and zoster vaccination in England&Wales: importance measures for correlated parameters | Zendy

Joke Bilcke | Zendy; AJ van Hoek | Zendy; Niel Hens | Zendy; Marc Aerts | Zendy; W. John Edmunds | Zendy; Philippe Beutels | Zendy

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Cost-effectiveness of varicella and zoster vaccination in England&Wales: importance measures for correlated parameters

Author(s) -

Joke Bilcke,

AJ van Hoek,

Niel Hens,

Marc Aerts,

W. John Edmunds,

Philippe Beutels

Publication year - 2010

Publication title -

procedia - social and behavioral sciences

Language(s) - English

Resource type - Journals

ISSN - 1877-0428

DOI - 10.1016/j.sbspro.2010.05.142

Subject(s) - interdependence , measure (data warehouse) , transmission (telecommunications) , econometrics , statistics , vaccination , medicine , epidemiology , variance (accounting) , computer science , mathematics , virology , economics , data mining , telecommunications , accounting , political science , law

This study aims to explore irregular relationships between input and outcomes in cost-effectiveness analysis, accounting for interdependencies between many input parameters. We used a dynamic infectious disease transmission model investigating the cost-effectiveness of varicella and zoster vaccination as a case study. Incremental costs and effects were used separately as the outcomes of interest, rather than the ratio between these, and a single R2 was calculated for groups of interdependent input parameters. Partial R2 was obtained as measure for the marginal proportion of variance explained. The most important input parameters were related to zoster epidemiology and disease transmission. In case of linear relationships, R2 is an easy to obtain importance measure, also in the presence of interdependent input parameters

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