Open AccessAssociation between inflammatory bowel disease and uveal melanoma: case report of two young adults and a literature review
Author(s) -
Salvatore Cozzi,
A. Slocker Escarpa,
Daniel Lorenzo Parra,
D. Najjari Jamal,
J. Maria Caminal Mitjana,
R Josep Maria Piulats,
F. Guedea Edo,
Cristina Miguélez
Publication year - 2019
Publication title -
reports of practical oncology and radiotherapy
Language(s) - English
Resource type - Journals
eISSN - 2083-4640
pISSN - 1507-1367
DOI - 10.1016/j.rpor.2018.10.002
Subject(s) - medicine , melanoma , inflammatory bowel disease , ulcerative colitis , disease , immune system , cancer , dermatology , immunology , oncology , cancer research
Uveal melanoma is a rare tumour caused by genetic factors and alterations in the immune response. Inflammatory bowel disease (IBD) is a multifactorial chronic inflammatory disorder characterized by an inappropriate or excessive immune response. The two main types of IBD are Crohn's disease (CD) and ulcerative colitis (UC). A diagnosis of IBD and the use of immunosuppressive drugs are both independently associated with an increased risk of developing skin melanoma. The association between IBD and uveal melanoma (UM) has not been previously described.